Synthesis of (1, 4)-naphthoquinono-[3, 2-c]-1H-pyrazoles and their (1, 4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents

VK Tandon, DB Yadav, AK Chaturvedi…

Index: Tandon, Vishnu K.; Yadav, Dharmendra B.; Chaturvedi, Ashok K.; Shukla, Praveen K. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 13 p. 3288 - 3291

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Citation Number: 63

Abstract

A series of (1, 4)-naphthoquinono [3, 2-c]-1H-pyrazoles and their (1, 4)- naphthohydroquinone derivatives 2–7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure–activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also ...