Mannich reaction. 6-Alkoxytetrahydro-5, 5-dimethyl-1, 3-oxazines

PY Johnson, RB Silver, MM Davis

文献索引：Johnson,P.Y. et al. Journal of Organic Chemistry, 1973 , vol. 38, # 21 p. 3753 - 3757

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被引用次数: 6

摘要

Results The original reactions of isobutyraldehyde with formaldehyde and primary amine hydrochlorides were reported in 1932 by Mannich and Wiedera4 When they used the hydrochloride salts of small amines, such as methylamine, they found that a novel dimer, 8a, of the desired secondary/?-amino aldehyde, 4a, was formed in 40% yield. They also noted some formation of amino aldehyde 4a; however, it was observed to self-condense upon ...