前往化源商城

An efficient route to all eight stereoisomers of a tri-functionalised cyclopentane scaffold for drug discovery

…, SJC Taylor, DA Chaplin, G Casy, R McCague

文献索引：Smith, Mark E.B.; Lloyd, Michael C.; Derrien, Nadine; Lloyd, Richard C.; Taylor, Stephen J.C.; Chaplin, David A.; Casy, Guy; McCague, Raymond Tetrahedron Asymmetry, 2001 , vol. 12, # 5 p. 703 - 705

全文：HTML全文

被引用次数: 21

摘要

3-(tert-Butoxycarbonylamino)-4-hydroxycyclopentanecarboxylic acid methyl esters are conformationally rigid and potentially valuable scaffolds for pharmaceutical discovery. 1 We have recently described an approach to these targets that is primarily concerned with the selectivity of hydrogenation reactions on cyclopent-1-enecarboxylate intermediates. 2 Epoxidations with Oxone® were employed to introduce the oxygen functionality, but we encountered poor volume efficiency and low ...

 相关合成线路
氯甲酸甲酯结构式

79-22-1

氯甲酸甲酯

(1S,3R,4S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-hydroxycyclopentanecarboxylic acid结构式

952708-31-5

(1S,3R,4S)-3-({...

~93%

(1R,2S,4S)-N-BOC-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-14-3

(1R,2S,4S)-N-BO...

(1R,4S)-4-(叔丁氧基羰基氨基)环戊-2-烯羧酸甲酯结构式

251326-99-5

(1R,4S)-4-(叔丁氧基...

~%

(1S,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

262280-14-8

(1S,2S,4R)-N-Bo...

(3R,4S)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid结构式

329910-36-3

(3R,4S)-4-tert-...

~%

(1S,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

262280-14-8

(1S,2S,4R)-N-Bo...

(1R,4S)-4-氨基环戊-2-烯甲酸结构式

134003-04-6

(1R,4S)-4-氨基环戊-2-烯甲酸

~%

(1S,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

262280-14-8

(1S,2S,4R)-N-Bo...

氮杂双环结构式

49805-30-3

氮杂双环

~%

(1S,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

262280-14-8

(1S,2S,4R)-N-Bo...

(1S,2R,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-23-4

(1S,2R,4R)-N-Bo...

~%

(1S,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

262280-14-8

(1S,2S,4R)-N-Bo...

(1R,3S,4R)-3-((tert-Butoxycarbonyl)amino)-4-hydroxycyclopentane-1-carboxylic acid结构式

927870-60-8

(1R,3S,4R)-3-((...

~%

(1S,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

262280-14-8

(1S,2S,4R)-N-Bo...

(1R,4S)-4-(叔丁氧基羰基氨基)环戊-2-烯羧酸甲酯结构式

251326-99-5

(1R,4S)-4-(叔丁氧基...

~%

(1S,2S,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-19-8

(1S,2S,4S)-N-Bo...

(3R,4S)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid methyl ester结构式

329910-37-4

(3R,4S)-4-tert-...

~%

(1S,2S,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-19-8

(1S,2S,4S)-N-Bo...

(3R,4S)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid结构式

329910-36-3

(3R,4S)-4-tert-...

~%

(1S,2S,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-19-8

(1S,2S,4S)-N-Bo...

(1S,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-21-2

(1S,2R,4S)-N-Bo...

~%

(1S,2S,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-19-8

(1S,2S,4S)-N-Bo...

(1R,4S)-4-氨基环戊-2-烯甲酸结构式

134003-04-6

(1R,4S)-4-氨基环戊-2-烯甲酸

~%

(1S,2S,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-19-8

(1S,2S,4S)-N-Bo...

氮杂双环结构式

49805-30-3

氮杂双环

~%

(1S,2S,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-19-8

(1S,2S,4S)-N-Bo...

(1S,4R)-4-[[叔丁氧羰基]氨基]-2-环戊烯-1-羧酸甲酯结构式

168683-02-1

(1S,4R)-4-[[叔丁氧...

~%

(1R,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-17-6

(1R,2S,4R)-N-Bo...

(3AR,5R,6R,6AR)-6-溴-2-氧代-3,3A,4,5,6,6A-六氢环戊[D]恶唑-5-甲酸甲酯结构式

352226-71-2

(3AR,5R,6R,6AR)...

~%

(1R,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-17-6

(1R,2S,4R)-N-Bo...

(3S,4R)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid结构式

352226-72-3

(3S,4R)-4-tert-...

~%

(1R,2S,4R)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-17-6

(1R,2S,4R)-N-Bo...

methyl (1S,3R,4R)-3-acetoxy-4-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylate结构式

352226-76-7

methyl (1S,3R,4...

~98%

(1R,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-16-5

(1R,2R,4S)-N-Bo...

(1S,4R)-4-[[叔丁氧羰基]氨基]-2-环戊烯-1-羧酸甲酯结构式

168683-02-1

(1S,4R)-4-[[叔丁氧...

~%

(1R,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-16-5

(1R,2R,4S)-N-Bo...

(3AR,5R,6R,6AR)-6-溴-2-氧代-3,3A,4,5,6,6A-六氢环戊[D]恶唑-5-甲酸甲酯结构式

352226-71-2

(3AR,5R,6R,6AR)...

~%

(1R,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-16-5

(1R,2R,4S)-N-Bo...

(3S,4R)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid结构式

352226-72-3

(3S,4R)-4-tert-...

~%

(1R,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-16-5

(1R,2R,4S)-N-Bo...

(1S,4R)-4-甲基环戊-2-烯甲酸甲酯盐酸盐结构式

229613-83-6

(1S,4R)-4-甲基环戊-...

~%

(1R,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-16-5

(1R,2R,4S)-N-Bo...

(1R,2S,4S)-N-BOC-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-14-3

(1R,2S,4S)-N-BO...

~%

(1R,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-16-5

(1R,2R,4S)-N-Bo...

(1S,3R,4S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-hydroxycyclopentanecarboxylic acid结构式

952708-31-5

(1S,3R,4S)-3-({...

~%

(1R,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-16-5

(1R,2R,4S)-N-Bo...

(1R,4S)-4-(叔丁氧基羰基氨基)环戊-2-烯羧酸甲酯结构式

251326-99-5

(1R,4S)-4-(叔丁氧基...

~%

(1S,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-21-2

(1S,2R,4S)-N-Bo...

(3R,4S)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid结构式

329910-36-3

(3R,4S)-4-tert-...

~%

(1S,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-21-2

(1S,2R,4S)-N-Bo...

(1R,4S)-4-氨基环戊-2-烯甲酸结构式

134003-04-6

(1R,4S)-4-氨基环戊-2-烯甲酸

~%

(1S,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-21-2

(1S,2R,4S)-N-Bo...

氮杂双环结构式

49805-30-3

氮杂双环

~%

(1S,2R,4S)-N-Boc-1-氨基-2-羟基环戊烷-4-羧酸甲酯结构式

321744-21-2

(1S,2R,4S)-N-Bo...

(1R,4S)-4-氨基环戊-2-烯甲酸结构式

134003-04-6

(1R,4S)-4-氨基环戊-2-烯甲酸

~%

(1R,4S)-4-(叔丁氧基羰基氨基)环戊-2-烯羧酸甲酯结构式

251326-99-5

(1R,4S)-4-(叔丁氧基...


首页 |  期刊大全 |  MSDS查询 |  化工产品分类 |  生物活性化合物 |  关于我们 |  免责声明:知识产权问题请联系 service1@chemsrc.com
Copyright © 2024 ChemSrc All Rights Reserved