Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes

B Qu, X Li, M Guan, X Li, L Hai, Y Wu

文献索引：Qu, Boyi; Li, Xiaocen; Guan, Mei; Li, Xun; Hai, Li; Wu, Yong European Journal of Medicinal Chemistry, 2014 , vol. 72, p. 110 - 118

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被引用次数: 4

摘要

Abstract The new bifunctional cluster glucosides were designed and synthesized as liposome ligands for preparing novel liposome to achieve the effective delivery of drug formulations to brain by GLUT1. Docetaxel-loaded five liposomes were prepared successfully and tested in the animals. Results from the in vivo distribution study after iv administration of these five liposomes and blank-docetaxel indicated that the coupled ...