Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes

B Qu, X Li, M Guan, X Li, L Hai, Y Wu

Index: Qu, Boyi; Li, Xiaocen; Guan, Mei; Li, Xun; Hai, Li; Wu, Yong European Journal of Medicinal Chemistry, 2014 , vol. 72, p. 110 - 118

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Citation Number: 4

Abstract

Abstract The new bifunctional cluster glucosides were designed and synthesized as liposome ligands for preparing novel liposome to achieve the effective delivery of drug formulations to brain by GLUT1. Docetaxel-loaded five liposomes were prepared successfully and tested in the animals. Results from the in vivo distribution study after iv administration of these five liposomes and blank-docetaxel indicated that the coupled ...