Benzimidazole-and benzothiazole-quinones: excellent substrates for NAD (P) H: quinone oxidoreductase 1
…, MA Colucci, M Hassani, HD Beall, CJ Moody
文献索引：Newsome, Jeffery J.; Colucci, Marie A.; Hassani, Mary; Beall, Howard D.; Moody, Christopher J. Organic and Biomolecular Chemistry, 2007 , vol. 5, # 22 p. 3665 - 3673
A series of benzimidazole-and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD (P) H: quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.
