Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors

…, W Luo, PJ Quinn, Z Liu, RC Hider

文献索引：Ma, Yongmin; Luo, Wei; Quinn, Peter J.; Liu, Zudong; Hider, Robert C. Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6349 - 6362

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被引用次数: 205

摘要

The synthesis of a range of novel 3-hydroxypyridin-4-ones and 3-hydroxypyran-4-ones linked with different coumarin substituents is described. These compounds have been developed in order to provide a series of molecular probes for the quantification of intracellular labile iron pools. An evaluation of the effect of iron (III) on fluorescence intensity was undertaken. Chelation of iron (III) causes quenching of fluorescence. The relationship ...