Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors

…, W Luo, PJ Quinn, Z Liu, RC Hider

Index: Ma, Yongmin; Luo, Wei; Quinn, Peter J.; Liu, Zudong; Hider, Robert C. Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6349 - 6362

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Citation Number: 205

Abstract

The synthesis of a range of novel 3-hydroxypyridin-4-ones and 3-hydroxypyran-4-ones linked with different coumarin substituents is described. These compounds have been developed in order to provide a series of molecular probes for the quantification of intracellular labile iron pools. An evaluation of the effect of iron (III) on fluorescence intensity was undertaken. Chelation of iron (III) causes quenching of fluorescence. The relationship ...