Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15-or 16-alkylprostaglandins

JS Skotnicki, RE Schaub, KF Bernady…

文献索引：Skotnicki,J.S. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, # 12 p. 1551 - 1557

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被引用次数: 13

摘要

The synthesis of dl-11-deoxy-15-or 16-alkylprostaglandins by the conjugate addition of appropriately substituted lithium alanate or lithium cuprate reagents to several cyclopentenones is described as is the preparation of the requisite intermediate (E)-1-iodo-1- alkenyl compounds 4, 22, 23, and 31. The bronchodilator activity of these prostaglandin congeners is presented.