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Enantioselective Synthesis of anti?螃漫?Hydroxy?螃窿?Amido Esters by Asymmetric Transfer Hydrogenation in Emulsions

B Seashore??Ludlow, P Villo…

文献索引:Seashore-Ludlow, Brinton; Villo, Piret; Somfai, Peter Chemistry - A European Journal, 2012 , vol. 18, # 23 p. 7219 - 7223

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被引用次数: 16

摘要

Abstract Herein, we present two methods for an asymmetric transfer hydrogenation through the dynamic kinetic resolution of α-amido-β-ketoesters. These procedures yield the corresponding anti-β-hydroxy-α-amido esters in good yields and with good diastereo-and enantioselectivities. First, the scope of the reduction of α-amido-β-ketoesters by using triethylammonium formate azeotrope is examined. Then, an emulsion technology with ...