Organic letters

Rapid formation of N-glycopeptides via Cu (II)-promoted glycosylative ligation

R Joseph, FB Dyer, P Garner

文献索引：Dyer, Frank Brock; Park, Chung-Min; Joseph, Ryan; Garner, Philip Journal of the American Chemical Society, 2011 , vol. 133, # 50 p. 20033 - 20035

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被引用次数: 13

摘要

Herein is described the chemoselective Cu (II)-HOBt promoted chemical ligation of glycosylamines and peptide thioacids to give N-glycosylated peptides. The method is distinguished from other chemical approaches to peptide N-glycosylation in that (1) it can be employed in the presence of unprotected N-terminal and Lys side chain amines;(2) it is remarkably fast, going to completion in under 30 min; and (3) it produces glycopeptides ...