e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Organic letters
Rapid formation of N-glycopeptides via Cu (II)-promoted glycosylative ligation
R Joseph, FB Dyer, P Garner
Index: Dyer, Frank Brock; Park, Chung-Min; Joseph, Ryan; Garner, Philip Journal of the American Chemical Society, 2011 , vol. 133, # 50 p. 20033 - 20035
Herein is described the chemoselective Cu (II)-HOBt promoted chemical ligation of glycosylamines and peptide thioacids to give N-glycosylated peptides. The method is distinguished from other chemical approaches to peptide N-glycosylation in that (1) it can be employed in the presence of unprotected N-terminal and Lys side chain amines;(2) it is remarkably fast, going to completion in under 30 min; and (3) it produces glycopeptides ...
