Synthesis and biological evaluation of technetium-labeled d-glucose-MAG 3 derivative as agent for tumor diagnosis

ALB de Barros, VN Cardoso, L das Graças Mota…

文献索引：de Barros, Andre Luis Branco; Cardoso, Valbert Nascimento; Mota, Luciene das Gracas; Leite, Elaine Amaral; Oliveira, Monica Cristina de; Alves, Ricardo Jose Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2497 - 2499

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被引用次数: 21

摘要

A d-glucose-MAG3 derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio and moderate tumor-to-blood ratio. Thus, d-glucose-MAG3 is a potential agent for tumor diagnosis.