Quantitative structure–activity analyses of novel hydroxyphenylurea derivatives as antioxidants

…, H Kubota, M Yasuhara, Y Hashimura, T Suzuki…

文献索引：Nakao, Kazuya; Shimizu, Ryo; Kubota, Hitoshi; Yasuhara, Mikiko; Hashimura, Yoshimasa; Suzuki, Toshikazu; Fujita, Toshio; Ohmizu, Hiroshi Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 6 p. 849 - 868

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被引用次数: 37

摘要

A series of substituted hydroxyphenylureas was synthesized, the chemical structure of which was designed based on structures of natural antioxidants, vitamin E (α-tocopherol) and uric acid. They exhibited high inhibitory activity against lipid peroxidation. In order to gain an insight into the mechanism of the inhibition reaction, we analyzed their structure–activity relationships quantitatively. Electronic and steric effects of substituents on the phenolic ...