Synthesis and biological characterization of novel hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5, 6, 7, 8-tetrahydro-naphthalen-2-ol and their …

…, SK Venkataraman, XS Fei, R Kolhatkar…

文献索引：Dutta, Aloke K.; Venkataraman, Sylesh K.; Fei, Xiang-Shu; Kolhatkar, Rohit; Zhang, Shijun; Reith, Maarten E.A. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4361 - 4373

全文：HTML全文

被引用次数: 36

摘要

In a recent preliminary communication we described the development of a series of hybrid molecules for the dopamine D2 and D3 receptor subtypes. The design of these compounds was based on combining pharmacophoric elements of aminotetralin and piperazine molecular fragments derived from known dopamine receptor agonist and antagonist molecules. Molecules developed from this approach exhibited high affinity and selectivity ...