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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

[(3-Aryl-1, 2-benzisoxazol-6-yl) oxy] acetic acids. A new diuretic series

GM Shutske, LL Setescak, RC Allen…

文献索引：Shutske, Gregory M.; Setescak, Linda L.; Allen, Richard C.; Davis, Larry; Effland, Richard C.; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 36 - 44

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被引用次数: 33

摘要

Chemistry. The synthesis of benzisoxazoles has been reviewed? Most of the (1, 2- benzisoxazol) oxyacetic acids (13, Table I) were synthesized from 2-chlorobenzophenones 6 and 7 (Scheme I), which were obtained from appropriately substituted 3-chloroanisoles and aroyl chlorides under typical Friedel-Crafts conditions. The hydroxybenzophenones 6 were obtained either in two steps through the intermediacy of the methoxybenzophenones ...

(2-fluorophenyl)-(2-hydroxy-4-methoxyphenyl)methanone结构式

(2-fluorophenyl...

~%

溴克利那结构式

3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole结构式

3-(2-fluorophen...

~%

溴克利那结构式

7-bromo-3-(2-fluorophenyl)benzo[d]isoxazol-6-ol结构式

7-bromo-3-(2-fl...

~%

溴克利那结构式

(E)-2'-fluoro-2-hydroxy-4-methoxybenzophenone oxime结构式

(E)-2'-fluoro-2...

~%

溴克利那结构式

7-bromo-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole结构式

7-bromo-3-(2-fl...

~%

溴克利那结构式

未登录结构式

~%

溴克利那结构式

邻氟苯甲酰氯结构式

邻氟苯甲酰氯

~%

溴克利那结构式

间苯二甲醚结构式

间苯二甲醚

~%

溴克利那结构式

2,3-二氯茴香醚结构式

2,3-二氯茴香醚

邻氟苯甲酰氯结构式

邻氟苯甲酰氯

~71%

(2,3-dichloro-4-methoxyphenyl)-(2-fluorophenyl)methanone结构式

(2,3-dichloro-4...

ethyl [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetate结构式

ethyl [[7-chlor...

~63%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

7-Chloro-6-hydroxy-3-(2-fluorophenyl)-1,2-benzisoxazole结构式

7-Chloro-6-hydr...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

邻氟苯甲酰氯结构式

邻氟苯甲酰氯

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

2,3-二氯茴香醚结构式

2,3-二氯茴香醚

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

2-氯-1,3-二甲氧基苯结构式

2-氯-1,3-二甲氧基苯

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

(2,3-dichloro-4-methoxyphenyl)-(2-fluorophenyl)methanone结构式

(2,3-dichloro-4...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

2,3-dichloro-4-hydroxy-2'-fluoro-benzophenone结构式

2,3-dichloro-4-...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone结构式

3-chloro-2'-flu...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

7-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole结构式

7-chloro-3-(2-f...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

2,3-dichloro-2'-fluoro-4-hydroxybenzophenone oxime结构式

2,3-dichloro-2'...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

(E)-3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone oxime结构式

(E)-3-chloro-2'...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

(E)-3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone O-acetyl oxime结构式

(E)-3-chloro-2'...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

间苯二甲醚结构式

间苯二甲醚

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid结构式

((7-chloro-3-(2...

邻氟苯甲酰氯结构式

邻氟苯甲酰氯

间苯二甲醚结构式

间苯二甲醚

~79%

(2-fluorophenyl)-(2-hydroxy-4-methoxyphenyl)methanone结构式

(2-fluorophenyl...