[(3-Aryl-1, 2-benzisoxazol-6-yl) oxy] acetic acids. A new diuretic series

GM Shutske, LL Setescak, RC Allen…

Index: Shutske, Gregory M.; Setescak, Linda L.; Allen, Richard C.; Davis, Larry; Effland, Richard C.; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 36 - 44

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Citation Number: 33

Abstract

Chemistry. The synthesis of benzisoxazoles has been reviewed? Most of the (1, 2- benzisoxazol) oxyacetic acids (13, Table I) were synthesized from 2-chlorobenzophenones 6 and 7 (Scheme I), which were obtained from appropriately substituted 3-chloroanisoles and aroyl chlorides under typical Friedel-Crafts conditions. The hydroxybenzophenones 6 were obtained either in two steps through the intermediacy of the methoxybenzophenones ...

 Related Synthetic Route
(2-fluorophenyl)-(2-hydroxy-4-methoxyphenyl)methanone Structure

3119-88-8

(2-fluorophenyl...

~%

Brocrinat Structure

72481-99-3

Brocrinat

3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole Structure

72483-09-1

3-(2-fluorophen...

~%

Brocrinat Structure

72481-99-3

Brocrinat

7-bromo-3-(2-fluorophenyl)benzo[d]isoxazol-6-ol Structure

72481-98-2

7-bromo-3-(2-fl...

~%

Brocrinat Structure

72481-99-3

Brocrinat

(E)-2'-fluoro-2-hydroxy-4-methoxybenzophenone oxime Structure

79938-22-0

(E)-2'-fluoro-2...

~%

Brocrinat Structure

72481-99-3

Brocrinat

7-bromo-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole Structure

72483-13-7

7-bromo-3-(2-fl...

~%

Brocrinat Structure

72481-99-3

Brocrinat

N/A Structure

79938-24-2

N/A

~%

Brocrinat Structure

72481-99-3

Brocrinat

2-Fluorobenzoyl chloride Structure

393-52-2

2-Fluorobenzoyl...

~%

Brocrinat Structure

72481-99-3

Brocrinat

1,3-Dimethoxybenzene Structure

151-10-0

1,3-Dimethoxybenzene

~%

Brocrinat Structure

72481-99-3

Brocrinat

1,2-Dichloro-3-methoxybenzene Structure

1984-59-4

1,2-Dichloro-3-...

2-Fluorobenzoyl chloride Structure

393-52-2

2-Fluorobenzoyl...

~71%

(2,3-dichloro-4-methoxyphenyl)-(2-fluorophenyl)methanone Structure

72498-53-4

(2,3-dichloro-4...

ethyl [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetate Structure

72498-56-7

ethyl [[7-chlor...

~63%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

7-Chloro-6-hydroxy-3-(2-fluorophenyl)-1,2-benzisoxazole Structure

72482-06-5

7-Chloro-6-hydr...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

2-Fluorobenzoyl chloride Structure

393-52-2

2-Fluorobenzoyl...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

1,2-Dichloro-3-methoxybenzene Structure

1984-59-4

1,2-Dichloro-3-...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

2-Chloro-1,3-dimethoxybenzene Structure

7051-15-2

2-Chloro-1,3-di...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

(2,3-dichloro-4-methoxyphenyl)-(2-fluorophenyl)methanone Structure

72498-53-4

(2,3-dichloro-4...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

2,3-dichloro-4-hydroxy-2'-fluoro-benzophenone Structure

72498-54-5

2,3-dichloro-4-...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone Structure

72482-07-6

3-chloro-2'-flu...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

7-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole Structure

72482-05-4

7-chloro-3-(2-f...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

2,3-dichloro-2'-fluoro-4-hydroxybenzophenone oxime Structure

72498-55-6

2,3-dichloro-2'...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

(E)-3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone oxime Structure

72582-52-6

(E)-3-chloro-2'...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

(E)-3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone O-acetyl oxime Structure

72582-53-7

(E)-3-chloro-2'...

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

1,3-Dimethoxybenzene Structure

151-10-0

1,3-Dimethoxybenzene

~%

((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid Structure

72498-57-8

((7-chloro-3-(2...

2-Fluorobenzoyl chloride Structure

393-52-2

2-Fluorobenzoyl...

1,3-Dimethoxybenzene Structure

151-10-0

1,3-Dimethoxybenzene

~79%

(2-fluorophenyl)-(2-hydroxy-4-methoxyphenyl)methanone Structure

3119-88-8

(2-fluorophenyl...


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