Tetrahedron

Silver-catalyzed synthesis of disubstituted isoxazoles by cyclization of alkynyl oxime ethers

…, Y Ikeda, A Sato, Y Ito, M Kakiuchi, H Shono, T Miyoshi…

文献索引：Ueda, Masafumi; Ikeda, Yuki; Sato, Aoi; Ito, Yuta; Kakiuchi, Maiko; Shono, Hiroko; Miyoshi, Tetsuya; Naito, Takeaki; Miyata, Okiko Tetrahedron, 2011 , vol. 67, # 25 p. 4612 - 4615

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被引用次数: 36

摘要

Abstract A facile and practical synthesis of 3, 5-disubstituted isoxazoles via a silver- catalyzed cyclization and subsequent protonation of alkynyl oxime ethers has been developed. The methodology was successfully applied to the synthesis of a biologically active isoxazolecarboxylic acid.