Design and synthesis of a novel class of CK2 inhibitors: application of copper-and gold-catalysed cascade reactions for fused nitrogen heterocycles

…, R Misu, S Naoe, Z Hou, T Kure, I Nakanishi…

文献索引：Suzuki, Yamato; Oishi, Shinya; Takei, Yoshinori; Yasue, Misato; Misu, Ryosuke; Naoe, Saori; Hou, Zengye; Kure, Tatsuhide; Nakanishi, Isao; Ohno, Hiroaki; Hirasawa, Akira; Tsujimoto, Gozoh; Fujii, Nobutaka Organic and Biomolecular Chemistry, 2012 , vol. 10, # 25 p. 4907 - 4915

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被引用次数: 16

摘要

Two classes of fused nitrogen heterocycles were designed as CK2 inhibitor candidates on the basis of previous structure–activity relationship (SAR) studies. Various dipyrrolo [3, 2-b: 2′, 3′-e] pyridine and benzo [g] indazole derivatives were prepared using transition-metal- catalysed cascade and/or multicomponent reactions. Biological evaluation of these candidates revealed that benzo [g] indazole is a promising scaffold for potent CK2 ...