Modified synthesis and antiangiogenic activity of linomide

SR Khan, A Mhaka, R Pili, JT Isaacs

文献索引：Khan, Saeed R.; Mhaka, Annastasiah; Pili, Roberto; Isaacs, John T. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 451 - 452

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被引用次数: 13

摘要

A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

10328-92-4

N-甲基靛红酸酐

~49%

Synthesis and biological evaluation of new 1, 2-dihydro-4-hy...

[Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088]

Synthesis and biological evaluation of new 1, 2-dihydro-4-hy...

[Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2075 - 2088]

Modified synthesis and antiangiogenic activity of linomide

[Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 451 - 452]