Ethyl Thioltrifluoroacetate as an Acetylating Agent with Particular Reference to Peptide Synthesis1

EE Schallenberg, M Calvin

文献索引：Schallenberg; Calvin Journal of the American Chemical Society, 1955 , vol. 77, p. 2779,2782

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被引用次数: 143

摘要

Recent developments in fluorine and sulfur chemistry have led us to investigate the use of ethyl thioltrifluoroacetate as an acetylating agent for amino acids and peptides in aqueous solution. The intense electrophilic property of the trifluoroacyl group is combined with the unusual aminophilicity of the sulfur atom in this thiol ester. The hydrolytic stability of the ester is in sharp contrast to the highly reactive trifluoroacetic anhydride which has been used to ...