Microwave??Promoted Copper??Free Sonogashira–Hagihara Couplings of Aryl Imidazolylsulfonates in Water

JF Cívicos, DA Alonso, C Nájera

文献索引：Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 203 - 208

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被引用次数: 23

摘要

Abstract Aryl imidazol-1-ylsulfonates have been efficiently cross-coupled with aryl-, alkyl-, and silylacetylenes in neat water under copper-free conditions at 110 C assisted by microwave irradiation. Using 0.5 mol% of an oxime palladacycle as precatalyst, 2- dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl (SPhos, 2 mol%) as ligand, hexadecyltrimethylammonium bromide (CTAB) as additive, and triethylamine (TEA) as ...