Novel synthetic approach to N-aryl-4-(3-pyridyl) thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet …
U Bhoga
文献索引：Bhoga, Umadevi European Journal of Medicinal Chemistry, 2007 , vol. 42, # 8 p. 1144 - 1150
A novel synthetic approach to N-aryl-4-(3-pyridyl) thiazol-2-amine and analogues using HMCM-41, a mesoporous aluminosilicate catalyst and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compounds N-(2′-flourophenyl)-4-(3-pyridyl) thiazol-2-amine (9e) was found to be the most potent, IC50= 4.84× 10− 7M.
