European journal of medicinal chemistry

Novel synthetic approach to N-aryl-4-(3-pyridyl) thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet …

U Bhoga

Index: Bhoga, Umadevi European Journal of Medicinal Chemistry, 2007 , vol. 42, # 8 p. 1144 - 1150

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Citation Number: 11

Abstract

A novel synthetic approach to N-aryl-4-(3-pyridyl) thiazol-2-amine and analogues using HMCM-41, a mesoporous aluminosilicate catalyst and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compounds N-(2′-flourophenyl)-4-(3-pyridyl) thiazol-2-amine (9e) was found to be the most potent, IC50= 4.84× 10− 7M.