Studies on the hydrogenation of 6??(hydroxymethyl) pyridine??2??carboxylates and its application to the synthesis of 6??(hydroxymethyl) piperidine??2??carboxylic acid …
…, L Anglada, A Pérez, A Sacristán…
文献索引：Bolos; Gubert; Anglada; Perez; Sacristan; Ortiz Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1493 - 1496
Abstract The synthesis of the novel amino acid 6-(hydroxymethyl)-2-piperidinecarboxylic acid (1a) and its ethyl ester 1b is reported. In the hydrogenation of 6-(hydroxymethyl) pyridine-2-carboxylates, hydrogenolysis of the alcohol group appeared as an unusual side reaction. Optimization of the reaction conditions allowed us to minimize hydrogenolysis and afforded pure 1.
