e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Studies on the hydrogenation of 6??(hydroxymethyl) pyridine??2??carboxylates and its application to the synthesis of 6??(hydroxymethyl) piperidine??2??carboxylic acid …
Abstract The synthesis of the novel amino acid 6-(hydroxymethyl)-2-piperidinecarboxylic acid (1a) and its ethyl ester 1b is reported. In the hydrogenation of 6-(hydroxymethyl) pyridine-2-carboxylates, hydrogenolysis of the alcohol group appeared as an unusual side reaction. Optimization of the reaction conditions allowed us to minimize hydrogenolysis and afforded pure 1.
