Synthesis and biological evaluation of phenstatin metabolites

…, B Rigo, JP Hénichart, D Le Broc-Ryckewaert…

文献索引：Ghinet, Alina; Rigo, Benoit; Henichart, Jean-Pierre; Le Broc-Ryckewaert, Delphine; Pommery, Jean; Pommery, Nicole; Thuru, Xavier; Quesnel, Bruno; Gautret, Philippe Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 6042 - 6054

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被引用次数: 18

摘要

Previous investigations on the incubation of phenstatin with rat and human microsomal fractions revealed the formation of nine main metabolites. The structures of eight of these metabolites have been now confirmed by synthesis and their biological properties have been reported. Eaton's reagent was utilized as a convenient condensing agent, allowing, among others, a simple multigram scale preparation of phenstatin. Synthesized ...