Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer

T Suzuki, N Fukazawa, K San-nohe…

文献索引：Suzuki, Tsuneji; Fukazawa, Nobuyuki; San-nohe, Kunio; Sato, Wakao; Yano, Osamu; Tsuruo, Takashi Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2047 - 2052

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被引用次数: 101

摘要

The effect of 24 newly synthesized quinoline derivatives on tumor cell multidrug resistance (MDR) was examined in vitro. At low concentrations, these compounds enhanced the accumulation of [3H] vincristine in K562/ADM cells and reversed tumor cell MDR. The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of ...