Cyproheptadine analogues: Synthesis, antiserotoninergic activity, and structure??activity relationships

…, R Dominguez, JA Seijas, MC Villaverde

文献索引：Loza; Sanz; Cadavid; Honrubia; Orallo; Fontenla; Calleja; Dot; Manaut; Cid; Dominguez; Seijas; Villaverde Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 11 p. 1090 - 1093

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被引用次数: 3

摘要

Abstract A series of cyproheptadine related compounds was synthesized and tested pharmacologically. In comparison with cyproheptadine, these compounds do not have a central ring and some contain groups other than N-methyl. Synthesis was carried out with low-valent titanium to generate the exocyclic double bond. The serotoninergic activity of the compounds was determined by standard determination of pA 2 (-log of the motor ...