Chemical Communications

Deracemisation and stereoinversion of α-amino acids using D-amino acid oxidase and hydride reducing agents

TM Beard, NJ Turner

文献索引：Beard, Timothy M; Turner, Nicholas J Chemical communications (Cambridge, England), 2002 , # 3 p. 246 - 247

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被引用次数: 51

摘要

Enzyme-catalysed processes have proven to be extremely useful for the synthesis of enantiopure amino-acids 1 and indeed a number of commercially important amino acids are now manufactured using enzymatic methods. 2 The most efficient reactions are those that result in >50% yield and in general this outcome can be achieved by either the asymmetric transformation of a prochiral substrate 3 or by a dynamic kinetic resolution. 4 A third approach involves the ...