Structure, DNA minor groove binding, and base pair specificity of alkyl-and aryl-linked bis (amidinobenzimidazoles) and bis (amidinoindoles)

…, NA Naiman, KA Ohemeng, RJ Lombardy…

文献索引：Fairley; Tidwell; Donkor; Naiman; Ohemeng; Lombardy; Bentley; Cory Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1746 - 1753

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被引用次数: 190

摘要

Figure 1. DNA binding molecules. is narrower than the minor groove in GC-rich sections. This narrow groove allows for optimal hydrophobic interaction between the drug and the walls of the groove. Hydrogen bonding with the bases on the floor of the groove appears to aid in drug positioning and contribute significantly to affinity. In compound 4 base pair specificity is conferred by van der Waals contacts between the adenine C2 hydrogen and ...