Lithium bromide catalyzed solvent free method for synthesis of 2-substituted benzimidazoles and imidazopyridines

DV Dekhane, SS Pawar, SV Gupta, MS Shingare…

文献索引：Dekhane, Deepak V.; Pawar, Shivaji S.; Gupta, Sunil V.; Shingare, Murlidhar S.; Thore, Shivaji N. Chinese Chemical Letters, 2010 , vol. 21, # 5 p. 519 - 523

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被引用次数: 10

摘要

The benzimidazole moiety is an important heterocyclic nucleus which has been used extensively in medicinal chemistry. Current clinical examples include the antihistamine astemizole [1], the anti-ulcerative esomeprazole [2] and albendazole [3], which is used to treat parasitic diseases. Benzimidazoles are a component of vitamin B12 and are related to the DNA base purine and the stimulant caffeine. Bisbenzimidazoles are being developed as DNA minor ...