Solvent effects in gold-catalysed A 3-coupling reactions

…, AK Brisdon, KR Flower, RG Pritchard, P Quayle

文献索引：Price, Gregory A.; Brisdon, Alan K.; Flower, Kevin R.; Pritchard, Robin G.; Quayle, Peter Tetrahedron Letters, 2014 , vol. 55, # 1 p. 151 - 154

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被引用次数: 6

摘要

The development of domino, multi-component and cascade reactions continues to be an area of intense academic interest 1 even though they were first documented over a century ago. 2 A particularly useful example is the 'A 3 -coupling reaction', an atom-economic, single step process for the preparation of synthetically useful propargyl amines 3 and 4 from aldehydes, alkynes and amines (Scheme 1). This reaction is found to be catalysed by a number of transition ...