Synthesis and antidiabetic activity of 2, 5-disubstituted-3-imidazol-2-yl-pyrrolo [2, 3-b] pyridines and thieno [2, 3-b] pyridines

…, A Sharma, R Tom, D Bandyopadhya, H Modi…

文献索引：Bahekar, Rajesh H.; Jain, Mukul R.; Jadav, Pradip A.; Prajapati, Vijay M.; Patel, Dipam N.; Gupta, Arun A.; Sharma, Ajay; Tom, Robby; Bandyopadhya, Debdutta; Modi, Honey; Patel, Pankaj R. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6782 - 6795

全文：HTML全文

被引用次数: 42

摘要

In the present investigation, two series of 2, 5-disubstituted-3-imidazol-2-yl-pyrrolo [2, 3-b] pyridines (2a–l) and thieno [2, 3-b] pyridines (3a–l) were designed as analogs of BL 11282 (1). The in vitro glucose dependent insulinotropic activity of all the test compounds was evaluated using RIN5F cell based assay and all the test compounds showed glucose and concentration dependent insulin secretion. The in vivo antidiabetic activities of most potent ...