Synthesis and antidiabetic activity of 2, 5-disubstituted-3-imidazol-2-yl-pyrrolo [2, 3-b] pyridines and thieno [2, 3-b] pyridines

…, A Sharma, R Tom, D Bandyopadhya, H Modi…

Index: Bahekar, Rajesh H.; Jain, Mukul R.; Jadav, Pradip A.; Prajapati, Vijay M.; Patel, Dipam N.; Gupta, Arun A.; Sharma, Ajay; Tom, Robby; Bandyopadhya, Debdutta; Modi, Honey; Patel, Pankaj R. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6782 - 6795

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Citation Number: 42

Abstract

In the present investigation, two series of 2, 5-disubstituted-3-imidazol-2-yl-pyrrolo [2, 3-b] pyridines (2a–l) and thieno [2, 3-b] pyridines (3a–l) were designed as analogs of BL 11282 (1). The in vitro glucose dependent insulinotropic activity of all the test compounds was evaluated using RIN5F cell based assay and all the test compounds showed glucose and concentration dependent insulin secretion. The in vivo antidiabetic activities of most potent ...