A simple and efficient one-pot multicomponent approach for the synthesis of 3, 5- disubstituted isoxazoles directly from corresponding aldehydes and terminal alkynes using recyclable montmorillonite clay supported Cu (II)/NaN3 catalytic system under aqueous conditions have been developed. The 'domino'one-pot MCR approach involves hydroxyamination of aldehydes followed by chlorination and then generation of reactive ' ...
