Montmorillonite clay Cu (II) catalyzed domino one-pot multicomponent synthesis of 3, 5-disubstituted isoxazoles

SB Bharate, AK Padala, BA Dar, RR Yadav, B Singh…

Index: Bharate, Sandip B.; Padala, Anil K.; Dar, Bashir A.; Yadav, Rammohan R.; Singh, Baldev; Vishwakarma, Ram A. Tetrahedron Letters, 2013 , vol. 54, # 27 p. 3558 - 3561

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Citation Number: 18

Abstract

A simple and efficient one-pot multicomponent approach for the synthesis of 3, 5- disubstituted isoxazoles directly from corresponding aldehydes and terminal alkynes using recyclable montmorillonite clay supported Cu (II)/NaN3 catalytic system under aqueous conditions have been developed. The 'domino'one-pot MCR approach involves hydroxyamination of aldehydes followed by chlorination and then generation of reactive ' ...