Tetrahedron letters

Enzymatic resolution of substituted mandelic acids

RF Campbell, K Fitzpatrick, T Inghardt, O Karlsson…

文献索引：Campbell, Robert F.; Fitzpatrick, Kevin; Inghardt, Tord; Karlsson, Olle; Nilsson, Kristina; Reilly, John E.; Yet, Larry Tetrahedron Letters, 2003 , vol. 44, # 29 p. 5477 - 5481

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被引用次数: 24

摘要

The kinetic resolution of racemic substrates by enzyme catalysis, especially efficient processes for lipase-catalyzed hydrolysis of esters and acylation of secondary alcohols, has become a standard reaction in organic synthesis. 1 During the course of our studies, we required the use of several enantiomerically pure substituted mandelic acids. Attempts to resolve several of these mandelic acids with various chiral amines via their diastereomeric salts were unsuccessful. 2., , and ...