Tetrahedron letters

A new synthesis of unsubstituted, 4 (5), and 4, 5-substituted 1H-imidazoles.

A Khalaj, M Ghafari

文献索引：Khalaj, A.; Ghafari, M. Tetrahedron Letters, 1986 , vol. 27, # 41 p. 5019 - 5020

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被引用次数: 12

摘要

During the course of another investigation it was required to examine the reaction of N- (aminomethyl) benzamide (1')with 1,2-dicarbonyl compounds (2a-h) in order to prepare acyl- imidazoles (3a-h) which are hydrolysed in mild acid or base to imidazoles (4a-h). ... C6H5CNHCH2-NH2+ RIC-C-R2 ___c C6H5C- "WN - ... (1) (2) (3) a: Rl,R2=H e: Rl,R2=i-pr b: Rl=H;R2=Me f: Rl=Ph;R2=H c: Rl,R2=Me g: Rl,R2=Ph d: Rl,R2=n-pr h: Rl=benzyl,R2=H