The Journal of organic chemistry

Copper-Catalyzed Synthesis of 2-Unsubstituted, N-Substituted Benzimidazoles

K Hirano, AT Biju, F Glorius

文献索引：Hirano, Keiichi; Biju, Akkattu T.; Glorius, Frank Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9570 - 9572

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被引用次数: 46

摘要

An efficient copper-catalyzed intramolecular arylation of formamidines forming 2- unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2, 6-diisopropylphenyl, or 2-tert- butylphenyl and tolerating various functional groups demonstrate the utility of this method.