Tetrahedron letters

Synthesis of cyclic and acyclic Nα-methyl-Nω-alkyl-l-arginine analogues

KP Kokko, HB Hooper, TA Dix

文献索引：Kokko, Kyle P.; Hooper, H. Brooks; Dix, Thomas A. Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2151 - 2153

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被引用次数: 6

摘要

A series of Nα-methyl-alkyl-l-arginine (Arg) analogues have been synthesized from inexpensive, commercially available starting materials. These analogues, once incorporated into pharmaceutically relevant peptides, are expected to increase binding affinity, receptor selectivity, lipophilicity, and stability as demonstrated with analogues of similar design and structure.