Tetrahedron letters

Adamantyl amino acid as γ-turn inducer for peptide

Y Kuroda, H Ueda, H Nozawa, H Ogoshi

文献索引：Kuroda, Yasuhisa; Ueda, Hiroshi; Nozawa, Hiroshi; Ogoshi, Hisanobu Tetrahedron Letters, 1997 , vol. 38, # 45 p. 7901 - 7904

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被引用次数: 22

摘要

The structures of six peptide mimics having different bulkiness and/or rigidity of the amino acids were investigated spectroscopically. Comparison of 1H NMR, IR spectra and HD exchange rate of the amide protons reveals that 2-amino-2-carboxyadamantane induces the high population of γ-turn conformation in the room temperature region and may be utilized as a promising γ-turn inducer for synthetic peptides.