Tetrahedron Letters

Palladium and copper catalyzed one-pot Sonogashira reaction of 2-nitroiodobenzenes with aryl acetylenes and subsequent regioselective hydration in water: …

S Ahammed, R Dey, BC Ranu

文献索引：Ahammed, Sabir; Dey, Raju; Ranu, Brindaban C. Tetrahedron Letters, 2013 , vol. 54, # 28 p. 3697 - 3701

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被引用次数: 3

摘要

An attempted Sonogashira reaction of 2-nitroiodobenzene and phenyl acetylene catalyzed by Pd (PPh3) 4/Cu in water in the presence of pyrrolidine proceeds with simultaneous regioselective hydration of the Sonogashira alkyne leading to the corresponding aryl ketone. A series of functionalized 2-(2-nitrophenyl)-1-aryl ethanones are obtained in high yields by this procedure.