(S)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-[125I] iodo-2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors

T De Paulis, A Janowsky, RM Kessler…

文献索引：Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E. Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033

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被引用次数: 39

摘要

From salicyclic acid, the two enantiomers of N-[(l-ethyl-2-pyrrolidinyl) methyl]-5-iodo-2- methoxybenzamide(6b) were prepared in a five-step synthesis. With use of Heindel's triazene method for introduction of the radionuclide, the iodine-125-labeled substituted benzamide was obtained with a calculated specific activity of 136 Ci/mmol and 14% radiochemical yield. For the preparation of the iodine-125-labeled benzamide with higher ...