Design and Synthesis of Novel Cyclooxygenase??1 Inhibitors as Analgesics: 5??Amino??2??ethoxy??N??(substituted??phenyl) benzamides

…, K Motoshima, A Tai, F Yazama, H Kakuta

文献索引：Fukai, Ryosuke; Zheng, Xiaoxia; Motoshima, Kazunori; Tai, Akihiro; Yazama, Futoshi; Kakuta, Hiroki ChemMedChem, 2011 , vol. 6, # 3 p. 550 - 560

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被引用次数: 3

摘要

Abstract We previously found that N-(4-aminophenyl)-4-trifluoromethylbenzamide (TFAP), a COX-1 inhibitor, exhibits an analgesic effect without causing gastric damage. Unfortunately, TFAP causes reddish purple coloration of urine, and its analgesic effect is less potent than that of indomethacin. Herein we describe our study focusing on the development of 4-and 5- amino-2-alkoxy-N-phenylbenzamide scaffolds, designed on the basis of the structures of ...