Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

JK Walker, SR Selness, RV Devraj…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2634 - 2638

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被引用次数: 15

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Herein we describe the synthesis and medicinal chemistry efforts that led to the identification of our recently disclosed clinical ... also allow us to incorporate substituents that would provide a handle to improve physical chemical properties. ...