Tetrahedron: Asymmetry

Synthesis of chiral pyrazoles and isoxazoles as constrained amino acids

M Falorni, G Giacomelli, AM Spanedda

文献索引：Falorni, Massimo; Giacomelli, Giampaolo; Spanedda, Anton Mario Tetrahedron Asymmetry, 1998 , vol. 9, # 17 p. 3039 - 3046

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被引用次数: 43

摘要

Nonproteinogenic amino acids play an important role in pharmaceutical applications; from this point of view, heteroaryl substituted α-amino acids have been recently considered.[1]A novel and important class of amino acid derived heterocycles is represented by isoxazoles and isothiazoles. During studies on ligands which activate neuronal nicotinic acetylcholine receptors for the palliative treatment for the symptoms of memory loss,[2]a series of novel 3,5- ...