Novel peptide isosteres that were designed to inhibit the binding of the HIV surface glycoprotein (gp120) to the T cell surface glycoprotein CD4

…, S Gorsuch, J Mann, S Yoshida

文献索引：Drew, Michael G. B.; Gorsuch, Stephen; Mann, John; Yoshida, Shimon Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1627 - 1636

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被引用次数: 7

摘要

The-and-isomers of (2 [])-2-[3′([])-3′-benzyl-3′-benzyloxycarbonylprop-1′-enyl]-- methoxycarbonylcarbonylpyrrolidines have been prepared from a Wittig reaction between ([])--Boc-prolinal and the phosphorus ylide from (2 [])-3-iodo-2-benzyl-1- triisopropylsilyloxypropane. In addition,(2 [])--methoxycarbonylcarbonyl-2-[(3′