Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase

T Tomašić, N Zidar, V Rupnik, A Kovač, D Blanot…

文献索引：Tomasic, Tihomir; Zidar, Nace; Rupnik, Veronika; Kovac, Andreja; Blanot, Didier; Gobec, Stanislav; Kikelj, Danijel; Masic, Lucija Peterlin Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 153 - 157

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被引用次数: 38

摘要

Mur ligases catalyze the biosynthesis of the UDP-MurNAc-pentapeptide precursor of peptidoglycan, an essential polymer of bacterial cell-wall. They constitute attractive targets for the development of novel antibacterial agents. Here we report on the synthesis of a series of 2, 4-diaminoquinazolines, quinazoline-2, 4 (1H, 3H)-diones, 5- benzylidenerhodanines and 5-benzylidenethiazolidine-2, 4-diones and their inhibitory ...