Mur ligases catalyze the biosynthesis of the UDP-MurNAc-pentapeptide precursor of peptidoglycan, an essential polymer of bacterial cell-wall. They constitute attractive targets for the development of novel antibacterial agents. Here we report on the synthesis of a series of 2, 4-diaminoquinazolines, quinazoline-2, 4 (1H, 3H)-diones, 5- benzylidenerhodanines and 5-benzylidenethiazolidine-2, 4-diones and their inhibitory ...
